TY - JOUR AB - Angiogenesis is required for tumor growth and metastasis and, therefore, represents a target for cancer treatment. While many factors have been implicated in promoting angiogenesis, vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. ZD6474 is a potent VEGF receptor-2 (VEGFR-2) tyrosine kinase inhibitor which also has activity against the epidermal growth factor receptor (EGFR) tyrosine kinase. The purpose of this study was to investigate the sensitivity of head and neck squamous cell carcinoma (HNSCC) cell lines to ZD6474, and to evaluate its antitumor efficacy on HNSCC xenografts. This is the first demonstration of antitumor effects of ZD6474 on HNSCC. In vitro ZD6474 displayed antiproliferative effects on HNSCC cells and inhibition of VEGFR-2 and EGFR pathways. In vivo ZD6474 displayed antitumor activity, induced apoptosis and antiangiogenic activity on nude mice bearing an established xenograft of YCU-H891 cells. These results suggest that ZD6474 has the potential to inhibit two key pathways in tumor growth via inhibition of VEGF-dependent tumor angiogenesis and via inhibition of EGFR-dependent tumor cell proliferation. AD - Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. t046028d@yokohama-cu.ac.jp null AU - Sano,Daisuke AU - Kawakami,Mariko AU - Fujita,Kyoko AU - Kimura,Machiko AU - Yamashita,Yukiko AU - Ishiguro,Yukari AU - Nishimura,Goshi AU - Matsuda,Hideki AU - Tsukuda,Mamoru DA - 2007/02/01 DO - 10.3892/or.17.2.289 EP - 295 IS - 2 JO - Oncol Rep PY - 2007 SN - 1021-335X 1791-2431 SP - 289 ST - Antitumor effects of ZD6474 on head and neck squamous cell carcinoma T2 - Oncology Reports TI - Antitumor effects of ZD6474 on head and neck squamous cell carcinoma UR - https://doi.org/10.3892/or.17.2.289 VL - 17 ER -