TY - JOUR AB - The plasminogen activator/plasmin system is one of the main protease systems involved in tumor cell invasion and metastasis. Our previous study has shown that plasmin degrades E-cadherin and promotes cell dissemination by downregulation of E-cadherin-mediated cell-cell adhesion in oral squamous cell carcinoma (SCC) cells. To examine the effect of downregulation of the plasminogen activator/plasmin system by α2-antiplasmin (α2-AP) on cell-cell adhesion mediated by E-cadherin in oral SCC cells, the oral SCC cell line SCCKN was stably transfected with α2-AP cDNA. Induction of α2-AP expression led to the inhibition of the proteolysis of E-cadherin by plasminogen activator/plasmin in SCC cells, resulting in the enhancement of the cell aggregation and the suppression of the cell motility. Moreover, α2-AP also reduced the ability of SCC cells to invade type I collagen gel, and suppressed tumorigenicity in vivo. These results suggested that downregulation of the plasminogen activator/ plasmin system by α2-AP might be a potent therapeutic approach to prevent the progression of oral SCC. AD - Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553, Japan. hayashiy@hiroshima-u.ac.jp null AU - Hayashido,Yasutaka AU - Hamana,Tomoaki AU - Ishida,Yasutaka AU - Shintani,Tomoaki AU - Koizumi,Koh-ichi AU - Okamoto,Tetsuji DA - 2007/02/01 DO - 10.3892/or.17.2.417 EP - 423 IS - 2 JO - Oncol Rep PY - 2007 SN - 1021-335X 1791-2431 SP - 417 ST - Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion T2 - Oncology Reports TI - Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion UR - https://doi.org/10.3892/or.17.2.417 VL - 17 ER -