TY - JOUR AB - We examined the relationship between chemosensitivity and the expression of mdr-1 and P-gp in ten human HCC cell lines. Expression of P-gp was detected immunohistochemically and the expression of mdr-1 mRNA by the reverse transcriptase polymerase chain reaction (RT-PCR). Chemosensitivity was determined by the MTT assay. P-gp was positive in nine of the ten lines. mdr-1 mRNA expression was found in five. All cells lines positive for mdr-1 mRNA expression expressed P-gp. We could not demonstrate a correlation between mdr-1 or P-gp expression and drug resistance. We conclude that drug-resistance in HCC cells depends not only on mdr-1 but also on other factor(s). AD - KUSHIRO ROUSAI HOSP,DEPT SURG,KITA KU,SAPPORO 060,JAPAN. AU - SASAKI,F AU - ISHIMURA,H AU - HATA,Y AU - UCHINO,J DA - 1995/03/01 DO - 10.3892/or.2.2.309 EP - 312 IS - 2 JO - Oncol Rep PY - 1995 SN - 1021-335X 1791-2431 SP - 309 ST - RELATIONSHIP BETWEEN MDR-1 MESSENGER-RNA EXPRESSION AND ANTICANCER DRUG-SENSITIVITY IN HUMAN HEPATOCELLULAR-CARCINOMA CELL-LINES T2 - Oncology Reports TI - RELATIONSHIP BETWEEN MDR-1 MESSENGER-RNA EXPRESSION AND ANTICANCER DRUG-SENSITIVITY IN HUMAN HEPATOCELLULAR-CARCINOMA CELL-LINES UR - https://doi.org/10.3892/or.2.2.309 VL - 2 ER -