TY - JOUR AB - Neuroendocrine tumors respond poorly to radiation and conventional chemotherapy, hence surgical removal of the neoplastic tissue is still the most effective way of treatment. In an attempt to find new therapeutic plant extracts of Christia vespertilionis (CV) their antitumor potential in human medullary thyroid carcinoma (MTC) and human small intestinal neuroendocrine tumor (SI-NET) cell lines were tested. Proliferation and viability were analyzed using cell counting and WST-1 assay. Apoptosis was determined by microscopy, luminescence assays for caspases 3/7, and expression studies of apoptosis-related genes. CV extracts showed antiprolife­rative and proapoptotic effects in all MTC and SI-NET cell lines, whereby high growth inhibition was observed by treatment with the ethylacetate-extracts (CV-45) in tumor cell lines but not in normal human fibroblasts. Furthermore CV-45 treatment resulted in alterations of gene expression of PDCD5, MTDH and TNFRSF10b in MTC as well as in SI-NET cells. The results indicate that Christia vespertilionis could serve as an anticancer therapeutic for treatment of neuroendocrine tumors. AD - Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck, Austria AU - Hofer,Daniela AU - Schwach,Gert AU - Ghaffari Tabrizi-Wizsy,Nassim AU - Sadjak,Anton AU - Sturm,Sonja AU - Stuppner,Hermann AU - Pfragner,Roswitha DA - 2013/06/01 DO - 10.3892/or.2013.2367 EP - 2226 IS - 6 JO - Oncol Rep KW - Christia vespertilionis neuroendocrine tumors apoptosis PDCD5 MTDH TNFRSF10b PY - 2013 SN - 1021-335X 1791-2431 SP - 2219 ST - Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells T2 - Oncology Reports TI - Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells UR - https://doi.org/10.3892/or.2013.2367 VL - 29 ER -