TY - JOUR AB - The HH signaling pathway is a ‘core’ signal transduction pathway in pancreatic cancer that promotes the tumorigenesis of pancreatic cancers via enhancing cell proliferation, increasing invasion and metastasis and protecting against apoptosis. In the present study, we found that HH signaling regulates autophagy in pancreatic cancer cells. Activation of HH signaling inhibits autophagy, while inhibition of the HH pathway induces autophagy. Although the role of autophagy in cell survival and apoptosis may depend on tumor type and the microenvironment, our data clearly demonstrated that GANT61-induced autophagy contributed to reduced viability and increased apoptosis in pancreatic cancer cells both in vivo and in vitro, and these effects were reversed by the autophagy inhibitor, 3-MA. We propose that HH signaling by regulating autophagy plays an important role in determining the cellular response to HH-targeted therapy in pancreatic cancer and further investigation of the interaction between autophagy and HH signaling is particularly important. AD - Department of General Surgery, Fourth Affiliated Hospital of Nantong University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, P.R. China Hepatobiliary Surgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, P.R. China Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China AU - Xu,Yonghua AU - An,Yong AU - Wang,Xuehao AU - Zha,Wenzhang AU - Li,Xiangcheng DA - 2014/02/01 DO - 10.3892/or.2013.2881 EP - 712 IS - 2 JO - Oncol Rep KW - Hedgehog signaling autophagy GANT61 pancreatic cancer apoptosis PY - 2014 SN - 1021-335X 1791-2431 SP - 707 ST - Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells T2 - Oncology Reports TI - Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells UR - https://doi.org/10.3892/or.2013.2881 VL - 31 ER -