TY - JOUR AB - Multiple myeloma (MM) is a disease with an adverse outcome and new therapeutic strategies are required to combat this disease. It is well known that tumor‑suppressor microRNA (miRNA) acts as a new potential anticancer agent. Accumulating evidence showed that microRNA-145 (miR-145) is a candidate tumor suppressor miRNA. However, whether miR-145 is involved in the development and progression of MM reamins to be determined. In the present study, we investigated the therapeutic potential of synthetic miR-145 against human MM cells in vitro and in vivo. The results showed that miR-145 was reduced in MM tissues and cell lines. Enforced expression of miR-145 by transfection with miR-145 mimics inhibited cell proliferation, migration, and the invasion abilities of H929 cells. Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profoundly decreased the levels of p-AKT and p-PI3K, which may contribute to some extent to the inhibition of MM cell proliferation and survival. The enforced expression of miR-145 in a xenograft mouse model suppressed tumor growth. In conclusion, our findings suggested that miR-145 may act as a tumor suppressor and contributes to the progression of MM. Additionally, miR-145 mimics is a potential therapeutic agent for the treatment of MM. AD - School of Pharmaceutical Sciences, Jilin University, Jilin, P.R. China First Hospital of Jilin University, Jilin, P.R. China Institute of Virology and AIDS Research, First Hospital of Jilin University, Jilin, P.R. China AU - Zhang,Qi AU - Yan,Weiqun AU - Bai,Yang AU - Xu,Hao AU - Fu,Changhao AU - Zheng,Wenwen AU - Zhu,Yingqiao AU - Ma,Jie DA - 2015/01/01 DO - 10.3892/or.2014.3591 EP - 456 IS - 1 JO - Oncol Rep KW - microRNA-145 microRNA multiple myeloma tumor growth PY - 2015 SN - 1021-335X 1791-2431 SP - 448 ST - Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125 T2 - Oncology Reports TI - Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo Retraction in /10.3892/or.2021.8125 UR - https://doi.org/10.3892/or.2014.3591 VL - 33 ER -