TY - JOUR AB - Gastric cancer (GC) remains the third most common cause of cancer deaths worldwide and carries a high rate of metastatic risk contributing to the main cause of treatment failure. An accumulation of data has resulted in a better understanding of the molecular network of GC, however, gaps still exist between the unique bio-resources and clinical application. MicroRNAs are an important part of non-coding RNAs and behave as major regulators of tumour biology, alongside their well-known roles as intrinsic factors of gene expression in cellular processes, via their post-transcriptional regulation of components of signalling pathways in a coordinated manner. Deregulation of the miR-1, -133 and -206 family plays a key role in tumorigenesis, progression, invasion and metastasis. This review aims to provide a summary of recent findings on the miR-1, -133 and -206 family in GC and how this knowledge might be exploited for the development of future miRNA-based therapies for the treatment of GC. AD - Department of Gastrointestinal Translational Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Haidian, Beijing 100142, P.R. China Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK AU - Xie,Meng AU - Dart,Dafydd ,Alwyn AU - Owen,Sioned AU - Wen,Xianzi AU - Ji,Jiafu AU - Jiang,Wenguo DA - 2016/09/01 DO - 10.3892/or.2016.4908 EP - 1198 IS - 3 JO - Oncol Rep KW - miR1-1 miR1-2 miR206 miR133A1 miR133A2 miR133b gastric cancer PY - 2016 SN - 1021-335X 1791-2431 SP - 1191 ST - Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review) T2 - Oncology Reports TI - Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review) UR - https://doi.org/10.3892/or.2016.4908 VL - 36 ER -