TY - JOUR AB - The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT‑26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor‑positive breast cancer MCF‑7 cells, acute lymphoblastic leukemia MOLT‑4 T‑cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT‑26, LNCaP, MOLT‑4 and Raji cell lines, as compared to control group (P<0.001), as demonstrated by Annexin V/PI staining. In in vivo experiments, mice bearing MCF‑7 and CT‑26 tumors exhibited a significant reduction in tumor volume in the quercetin‑treated group as compared to the control group (P<0.001). Taken together, quercetin, a naturally occurring compound, exhibits anticancer properties both in vivo and in vitro. AD - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran Students Research Committee, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Department of Cardiology, Larissa University Hospital, Larissa, Greece Department of Biochemistry and Biotechnology, Faculty of Animal Physiology‑Toxicology, University of Thessaly, Larissa, Greece Department of Anatomy‑Histology‑Embryology, Medical School, University of Crete, Greece SEC Nanotechnology, Engineering School, Far Eastern Federal University, Vladivostok, Russia Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion, Greece Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, Greece Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AU - Hashemzaei,Mahmoud AU - Delarami Far,Amin AU - Yari,Arezoo AU - Heravi,Reza ,Entezari AU - Tabrizian,Kaveh AU - Taghdisi,Seyed ,Mohammad AU - Sadegh,Sarvenaz ,Ekhtiari AU - Tsarouhas,Konstantinos AU - Kouretas,Dimitrios AU - Tzanakakis,George AU - Nikitovic,Dragana AU - Anisimov,Nikita ,Yurevich AU - Spandidos,Demetrios  ,A. AU - Tsatsakis,Aristides ,M. AU - Rezaee,Ramin DA - 2017/08/01 DO - 10.3892/or.2017.5766 EP - 828 IS - 2 JO - Oncol Rep KW - quercetin apoptosis cytotoxicity Annexin V/PI cancer treatment MTT assay PY - 2017 SN - 1021-335X 1791-2431 SP - 819 ST - Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo T2 - Oncology Reports TI - Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo UR - https://doi.org/10.3892/or.2017.5766 VL - 38 ER -