TY - JOUR AB - It is not well established whether miR-93 is involved in drug resistance and epithelial-mesenchymal transition (EMT) in breast cancer, and its underlying mechanism remains uncertain. In the present study, the expression differences of miR-93 between paired breast cancer tissues confirmed it is involved in the progression of breast cancer. Such a difference was also observed in doxorubicin-resistant and -sensitive cells. Overexpressed miR-93 in sensitive cells revealed increases in cellular proliferation and the expression levels of drug-resistant-related genes, and a decrease in sensitivity to doxorubicin. This demonstrated the relationship between miR-93 and breast cancer drug resistance. Simultaneously, EMT was confirmed in miR-93 overexpressing sensitive cells. This indicated the triadic relationship among miR-93, EMT and drug resistance in breast cancer. We applied the Dual-luciferase Reporter assay to expose the direct interaction between miR-93 and PTEN, which suggested that miR-93 contributes to inducing EMT and drug resistance of breast cancer cells by targeting PTEN. AD - Department of Human Anatomy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China Division of Endocrinlogy and Metabolism, State Key Laboratory of Biotherapy, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, P.R. China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China Biotherapy Laboratory of Gynecological Oncology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China AU - Chu,Shihua AU - Liu,Geng AU - Xia,Peixuan AU - Chen,Guoqing AU - Shi,Feng AU - Yi,Tao AU - Zhou,Hongying DA - 2017/10/01 DO - 10.3892/or.2017.5859 EP - 2407 IS - 4 JO - Oncol Rep KW - miR-93 EMT PTEN doxorubicin-resistance PY - 2017 SN - 1021-335X 1791-2431 SP - 2401 ST - miR-93 and PTEN: Key regulators of doxorubicin-resistance and EMT in breast cancer T2 - Oncology Reports TI - miR-93 and PTEN: Key regulators of doxorubicin-resistance and EMT in breast cancer UR - https://doi.org/10.3892/or.2017.5859 VL - 38 ER -