TY - JOUR AB - Hypoxia is a hallmark of progressive cancer. Hypoxic cancer cells trigger glycolysis in response to a decreased O2 supply to meet metabolic and bioenergetic demands. Meanwhile, these responses to hypoxia and alterations of the microenvironment promote cancer cell metastasis by increasing transcription of hypoxia-inducible factor (HIF)-regulated genes. However, the detailed mechanism by which hypoxia regulates cancer cell metastasis and glycolysis remains to be investigated. In the present study, we identified that metadherin (MTDH), a multifaceted oncogene, is involved in the regulation of head and neck squamous cell carcinoma (HNSCC) metastasis and invasion under hypoxic conditions. Furthermore, the study indicated that there is a positive feedback loop between HIF-1α and MTDH in HNSCC cells, and that hypoxia promotes HNSCC cell metastasis and epithelial-mesenchymal transition by mediating the HIF-1α-MTDH loop. These findings implicate HIF-1α-MTDH as a promising target for anticancer drugs in solid tumors, and help to explain the pro-tumorigenic and unfavorable effect of MTDH on HNSCC observed in our previous studies. AD - Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China Department of Otolaryngology Head and Neck Surgery, Loudi Central Hospital, Loudi, Hunan 417011, P.R. China Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumour Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China AU - Zhu,Gangcai AU - Peng,Fusen AU - Gong,Wei AU - She,Li AU - Wei,Ming AU - Tan,Haolei AU - Chen,Changhan AU - Zhang,Diekuo AU - Li,Guo AU - Huang,Donghai AU - Zhang,Xin AU - Liu,Yong DA - 2017/11/01 DO - 10.3892/or.2017.5949 EP - 2900 IS - 5 JO - Oncol Rep KW - head and neck squamous cell carcinoma MTDH HIF-1α hypoxia glycolysis metastasis PY - 2017 SN - 1021-335X 1791-2431 SP - 2893 ST - Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1α-MTDH loop T2 - Oncology Reports TI - Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1α-MTDH loop UR - https://doi.org/10.3892/or.2017.5949 VL - 38 ER -