TY - JOUR AB - Accumulating evidence has demonstrated that aberrant miRNAs were involved in carcinogenesis and tumor progression by regulating oncogenes or tumor suppressor expression. Dysregulation of miR-381 has been reported in different tumors. However, the clinical roles and underlying mechanism in non-small cell lung cancer (NSCLC) remains to be elucidated. We found the expression of miR-381 was significantly downregulated in both NSCLC tissues and cell lines. Clinical analysis revealed the reduced miR-381 was obviously associated with advanced TNM stage and lymph node metastasis. Moreover, we disclosed that miR-381 was a novel independent prognostic marker for predicting 5-year survival of NSCLC patients. The ectopic overexpression of miR-381 inhibited cell migration and invasion in vitro and in vivo. Notably, miR-381 could modulate LRH-1 by directly binding to its 3'-UTR. In clinical samples of NSCLC, miR-381 inversely correlated with LRH-1 expression, which performed positive roles in NSCLC migration and invasion. Alteration of LRH-1 expression at least partially abolished the migration and invasion of miR-381 on NSCLC cells. Here, we identified LRH-1 as a functional target of miR-381 in NSCLC. In conclusion, our data indicated that miR-381 inhibited migration and invasion of NSCLC by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC. AD - Department of Oncology, Cangnan Hospital Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Tumor Department of Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Department of Oncology, Zhejiang Tumor Hospital, Hangzhou, Zhejiang 310000, P.R. China AU - Tian,Chunyan AU - Li,Jun AU - Ren,Lili AU - Peng,Ren AU - Chen,Binbin AU - Lin,Yumei DA - 2017/11/01 DO - 10.3892/or.2017.5956 EP - 3077 IS - 5 JO - Oncol Rep KW - microRNA-381 non-small cell lung cancer LRH-1 migration invasion PY - 2017 SN - 1021-335X 1791-2431 SP - 3071 ST - MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640 T2 - Oncology Reports TI - MicroRNA-381 serves as a prognostic factor and inhibits migration and invasion in non-small cell lung cancer by targeting LRH-1 Retraction in /10.3892/or.2023.8640 UR - https://doi.org/10.3892/or.2017.5956 VL - 38 ER -