TY - JOUR AB - Luteolin (3,4,5,7‑tetrahydroxyflavone) is a natural flavonoid that has been found to exhibit anticancer properties in certain types of cancers. In the present study, the role of luteolin and its underlying mechanisms were explored in colorectal cancer (CRC) cells. First, the effects of luteolin on CRC cells proliferation, migration and invasion were examined by CCK‑8, wound healing and Transwell assays, respectively. It was demonstrated that luteolin had no effects on CRC cells proliferation while inhibited cells migration and invasion both in vitro and in vivo. Then, expression of pleiotrophin (PTN) and miR‑384 was detected in cells and CRC tissues by qPCR. Luteolin was found to upregulate miR‑384 and downregulate PTN expressions both in CRC cells and tissues. miR‑384 inhibition and PTN overexpression partially reversed the inhibition of HT‑29 cells migration and invasion induced by luteolin. Target analysis revealed that miR‑384 directly regulates PTN expression. The correlation analysis between PTN expression and clinical characteristics revealed that PTN expression was positively related to cancer progression. The present study demonstrated that luteolin exerts anticancer effects against CRC cells by modulating PTN via miR‑384 expression suggested that PTN may serve as a promising candidate for therapeutic applications in CRC treatment. AD - Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China Department of Colorectal Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Guangxing Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, P.R. China Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China AU - Yao,Yuanyuan AU - Rao,Chunhui AU - Zheng,Gang AU - Wang,Saisai DA - 2019/07/01 DO - 10.3892/or.2019.7136 EP - 141 IS - 1 JO - Oncol Rep KW - luteolin colorectal cancer miR‑384 PTN invasion metastasis PY - 2019 SN - 1021-335X 1791-2431 SP - 131 ST - Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis T2 - Oncology Reports TI - Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis UR - https://doi.org/10.3892/or.2019.7136 VL - 42 ER -