TY - JOUR AB - Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer. AD - Medicine Faculty, National University of Colombia, Bogotá 111321, Colombia School of Biochemistry, Medicine and Science Faculty, San Sebastián University, Santiago 7510157, Chile Statistics Department, National University of Colombia, Bogotá 111321, Colombia Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá 110231, Colombia AU - Otálora‑Otálora,Beatriz ,Andrea AU - Henríquez,Berta AU - López‑Kleine,Liliana AU - Rojas,Adriana DA - 2019/07/01 DO - 10.3892/or.2019.7149 EP - 19 IS - 1 JO - Oncol Rep KW - runt‑related transcription factor oncogenes tumor suppressor transcription factor cancer PY - 2019 SN - 1021-335X 1791-2431 SP - 3 ST - RUNX family: Oncogenes or tumor suppressors (Review) T2 - Oncology Reports TI - RUNX family: Oncogenes or tumor suppressors (Review) UR - https://doi.org/10.3892/or.2019.7149 VL - 42 ER -