TY - JOUR AB - Calcium‑dependent activator protein for secretion 1 (CAPS1) has been reported to promote metastasis in colorectal cancer (CRC), however, the underlying mechanisms have not yet been elucidated. The present study revealed that exosomes derived from CAPS1‑overexpressing CRC cells could enhance the migration of normal colonic epithelial FHC cells. GW4869, an inhibitor of exosomes, could attenuate the migration of FHC cells. Furthermore, liquid chromatography‑mass spectrometry (LC‑MS) and bioinformatics analysis demonstrated that overexpression of CAPS1 could alter the expression pattern of exosomal proteins involved in cell migration. Bone morphogenetic protein 4, which may serve vital roles in the process of CAPS1‑induced cell migration, was downregulated in the exosomes. In summary, the present results demonstrated that CAPS1 promotes cell migration by regulating exosomes. Inhibiting the secretion of exosomes may be helpful for the treatment of patients with metastatic CRC. AD - Key Laboratory of Glycoconjugate Research (Ministry of Public Health), Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai 200032, P.R. China AU - Wu,Bingrui AU - Sun,Dalong AU - Ma,Lijie AU - Deng,Yiran AU - Zhang,Si AU - Dong,Ling AU - Chen,She AU - Wu,Bingrui AU - Sun,Dalong AU - Ma,Lijie AU - Deng,Yiran AU - Zhang,Si AU - Dong,Ling AU - Chen,She AU - Wu,Bingrui AU - Sun,Dalong AU - Ma,Lijie AU - Deng,Yiran AU - Zhang,Si AU - Dong,Ling AU - Chen,She DA - 2019/12/01 DO - 10.3892/or.2019.7361 EP - 2536 IS - 6 JO - Oncol Rep KW - CAPS1 exosome colorectal cancer liquid chromato­graphy‑mass spectrometry proteomics BMP4 PY - 2019 SN - 1021-335X 1791-2431 SP - 2528 ST - Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration T2 - Oncology Reports TI - Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration UR - https://doi.org/10.3892/or.2019.7361 VL - 42 ER -