TY - JOUR AB - Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. A cross‑sectional study was completed. A total of 8,634 patients who underwent stomach biopsy and who had no gastrectomy history were enrolled in the study. The patients were divided into two groups according to the presence or absence of gastric xanthelasma. The relationship between gastric xanthelasma and demographic characteristics (including age and sex), endoscopic features (including peptic ulcer, bile reflux, and gastric poly), or pathological features (including atrophy, intestinal metaplasia, H. pylori, dysplasia, and gastric cancer) was analyzed. Age/sex matched analysis was also performed to exclude the influence of age and sex. The results revealed that out of the 8,634 patients, 3.54% patients had xanthelasma. Gastric xanthelasma was significantly associated with age (55.76 vs. 49.17 years, P<0.0001), duodenal ulcer (OR 0.860, 95% CI 0.369‑0.923), atrophy (OR 1.839, 95% CI 1.432‑2.362), and intestinal metaplasia (OR 3.296, 95% CI 2.612‑4.159). Binary logistic analysis revealed that age (OR 1.027, 95% CI 1.017‑1.037) and intestinal metaplasia (OR 2.700, 95% CI 2.090‑3.487) were independently related to gastric xanthelasma. Age/sex matched control binary logistic analysis revealed that gastric xanthelasma was significantly associated with presence of intestinal metaplasia (OR 2.338, 95% CI 1.659‑3.297). There was no difference in the number (P=0.427) and location (P>0.05) of gastric xanthelasma for intestinal metaplasia. In conclusion, gastric xanthelasma may be an independent endoscopic warning sign of intestinal metaplasia. AD - Department of Gastroenterology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China Department of Oncology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201801, P.R. China AU - Xiao,Dinghong AU - Tong,Xin AU - Yuan,Xiaoqin AU - Wu,Yunlin AU - Chen,Ping DA - 2020/09/01 DO - 10.3892/or.2020.7651 EP - 1281 IS - 3 JO - Oncol Rep KW - gastric xanthelasma intestinal metaplasia atrophy PY - 2020 SN - 1021-335X 1791-2431 SP - 1275 ST - Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study T2 - Oncology Reports TI - Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study UR - https://doi.org/10.3892/or.2020.7651 VL - 44 ER -