TY - JOUR AB - Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in tumor migration and invasion. Numerous studies have shown that dysregulation of the Wnt/β‑catenin signaling pathway gives rise to EMT, which is characterized by nuclear translocation of β‑catenin and E‑cadherin suppression. Wnt/β‑catenin signaling was confirmed to be affected by microRNAs (miRNAs), several of which are down‑ or upregulated in metastatic cancer cells, indicating their complex roles in Wnt/β‑catenin signaling. In this review, we demonstrated the targets of various miRNAs in altering Wnt/β‑catenin signaling to promote or inhibit EMT, which may elucidate the underlying mechanism of EMT regulation by miRNAs and provide evidence for potential therapeutic targets in the treatment of invasive tumors. AD - Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China Department of Big Data Research of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China Department of Pediatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Formula Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China Department of Oncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518000, P.R. China AU - Lei,Yuhe AU - Chen,Lei AU - Zhang,Ge AU - Shan,Aiyun AU - Ye,Chunfeng AU - Liang,Bin AU - Sun,Jiayu AU - Liao,Xin AU - Zhu,Changfeng AU - Chen,Yueyue AU - Wang,Jing AU - Zhang,Enxin AU - Deng,Lijuan DA - 2020/10/01 DO - 10.3892/or.2020.7703 EP - 1313 IS - 4 JO - Oncol Rep KW - microRNA Wnt/β‑catenin signaling epithelial‑ mesenchymal transition cancer metastasis cancer therapy PY - 2020 SN - 1021-335X 1791-2431 SP - 1299 ST - MicroRNAs target the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (Review) T2 - Oncology Reports TI - MicroRNAs target the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (Review) UR - https://doi.org/10.3892/or.2020.7703 VL - 44 ER -