TY - JOUR AB - Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours. AD - Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, P.R. China Qinghai Institute of Health Sciences, Xining, Qinghai 810000, P.R. China Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, P.R. China AU - Zhang,Yanhua AU - Li,Yue AU - Wang,Quanyue AU - Su,Bo AU - Xu,Hui AU - Sun,Yang AU - Sun,Pei AU - Li,Rumeng AU - Peng,Xiaochun AU - Cai,Jun DA - 2020/12/01 DO - 10.3892/or.2020.7807 EP - 2396 IS - 6 JO - Oncol Rep KW - tumour Ras p21 protein activator 1 microRNA Ras therapy PY - 2020 SN - 1021-335X 1791-2431 SP - 2386 ST - Role of RASA1 in cancer: A review and update (Review) T2 - Oncology Reports TI - Role of RASA1 in cancer: A review and update (Review) UR - https://doi.org/10.3892/or.2020.7807 VL - 44 ER -