TY - JOUR AB - Renal cell carcinoma (RCC) is a common type of kidney cancer that lacks effective therapeutic options. Ginsenoside compound K (CK), an active metabolite of ginsenosides, has been reported to induce apoptosis in various types of cancer cells. However, the effects of CK in RCC remain to be elucidated. Thus, the aim of the present study was to investigate the antitumor effects of CK on RCC cells. The effects of CK on the proliferation, migration, invasion, cell cycle and apoptosis of RCC cell lines (Caki‑1 and 768‑O) were investigated using MTT, wound healing, Transwell and flow cytometry assays, respectively. Changes in the expression levels of long non‑coding RNAs (lncRNAs) and proteins were measured via reverse transcription‑quantitative PCR and western blotting, respectively. Transfections with testis associated oncogenic (THOR) small interfering RNA and pcDNA were performed to knock down and overexpress lncRNA THOR, respectively. It was found that CK could effectively inhibit the proliferation, migration and invasion of RCC cells. CK also induced cell cycle arrest and caspase‑dependent apoptosis in RCC cells. Furthermore, the generation of reactive oxygen species and inhibition of the lncRNA THOR played important roles in the antitumour effects of CK in RCC cells. The present data revealed that CK was a potent antitumour agent against RCC. AD - Department of Urology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China Department of Urology, Ningbo Urology and Nephrology Hospital, Ningbo, Zhejiang 315100, P.R. China Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, Zhejiang 315210, P.R. China AU - Chen,Shuqiu AU - Ye,Haihong AU - Gong,Fanger AU - Mao,Suming AU - Li,Cong AU - Xu,Bin AU - Ren,Yu AU - Yu,Rui DA - 2021/04/01 DO - 10.3892/or.2021.7989 IS - 4 JO - Oncol Rep KW - renal cell carcinoma ginsenoside compound K reactive oxygen species apoptosis long non‑coding RNA testis associated oncogenic lncRNA PY - 2021 SN - 1021-335X 1791-2431 SP - 38 ST - Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR T2 - Oncology Reports TI - Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR UR - https://doi.org/10.3892/or.2021.7989 VL - 45 ER -