TY - JOUR
AB - The present study aimed to investigate the role of partner of NOB1 homolog (PNO1) in esophageal cancer (EC). The expression levels of PNO1 in EC were primarily analyzed using data obtained from databases. PNO1 expression was also knocked down in EC cells (Eca‑109 and TE1) to determine the biological effects of PNO1 on tumorigenesis in vitro and in vivo. In addition, possible downstream targets of PNO1 in EC were identified. The expression levels of PNO1 were upregulated in the tumor tissues compared with that noted in normal tissues. Moreover, the knockdown (KD) of PNO1 suppressed cell proliferation, migration and invasion, and promoted cell apoptosis (P<0.05). Furthermore, the protein expression levels of AKT1, Twist, Myc, mTOR, matrix metalloproteinase 2 (MMP2), nuclear factor (NF)‑κB p65 and β‑catenin 1 (CTNNB1) were downregulated following the KD of PNO1 in Eca‑109 cells (P<0.05). In addition, the overexpression of CTNNB1 reversed the effects of PNO1 KD in Eca‑109 cells (P<0.05). In conclusion, the findings of the present study suggest that PNO1 promotes EC progression by regulating AKT1, Twist, Myc, mTOR, MMP2, NF‑κB p65 and CTNNB1 expression.
AD - Department of Thoracic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China
Department of Thoracic Surgery, Huzhou Central Hospital, Huzhou, Zhejiang 310000, P.R. China
AU - Wang,Guowen
AU - Li,Qicai
AU - Li,Chuankui
AU - Duan,Guixin
AU - Sang,Haiwei
AU - Dong,Haijun
AU - Yang,Yifan
AU - Ma,Chang
AU - Tao,Tao
DA - 2021/05/01
DO - 10.3892/or.2021.8036
IS - 5
JO - Oncol Rep
KW - partner of NOB1 homolog
CTNNB1
esophageal cancer
AKT1
cell proliferation
PY - 2021
SN - 1021-335X
1791-2431
SP - 85
ST - Knockdown of PNO1 inhibits esophageal cancer progression
T2 - Oncology Reports
TI - Knockdown of PNO1 inhibits esophageal cancer progression
UR - https://doi.org/10.3892/or.2021.8036
VL - 45
ER -