TY - JOUR
AB - Extracellular acidosis is associated with various immunopathological states. The microenvironment of numerous solid tumours and inflammatory responses during acute or chronic infection are all related to a pH range of 5.5‑7.0. The relationship between inflammation and immune escape, cancer metabolism, and immunologic suppression drives researchers to focus on the effects of low pH on diverse components of disease immune monitoring. The potential effect of low extracellular pH on the immune function reveals the importance of pH in inflammatory and immunoreactive processes. In this review, the mechanism of how pH receptors, including monocarboxylate transporters (MCTs), Na+/H+ exchanger 1, carbonic anhydrases (CAs), vacuolar‑ATPase, and proton‑sensing G‑protein coupled receptors (GPCRs), modulate the immune system in disease, especially in cancer, were studied. Their role in immunocyte growth and signal transduction as part of the immune response, as well as cytokine production, have been documented in great detail. Currently, immunotherapy strategies have positive therapeutic effects for patients. However, the acidic microenvironment may block the effect of immunotherapy through compensatory feedback mechanisms, leading to drug resistance. Therefore, we highlight promising therapeutic developments regarding pH manipulation and provide a framework for future research.
AD - Department of The Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100020, P.R. China
The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
Department of Otolaryngology‑Head and Neck Surgery, Beijing Tongren Hospital, Beijing 100010, P.R. China
AU - Cao,Lin
AU - Huang,Tianqiao
AU - Chen,Xiaohong
AU - Li,Weisha
AU - Yang,Xingjiu
AU - Zhang,Wenlong
AU - Li,Mengyuan
AU - Gao,Ran
DA - 2021/10/01
DO - 10.3892/or.2021.8179
IS - 4
JO - Oncol Rep
KW - pH regulation
immunity
acidosis
microenvironment
therapeutic inhibitors
PY - 2021
SN - 1021-335X
1791-2431
SP - 228
ST - Uncovering the interplay between pH receptors and immune cells: Potential drug targets (Review)
T2 - Oncology Reports
TI - Uncovering the interplay between pH receptors and immune cells: Potential drug targets (Review)
UR - https://doi.org/10.3892/or.2021.8179
VL - 46
ER -