TY - JOUR AB - Hepatocellular carcinoma (HCC) represents almost 80% of all liver cancers, is the sixth most common cancer and is the second‑highest cause of cancer‑related deaths worldwide. Protein tyrosine phosphatases (PTPs), which are encoded by the largest family of phosphatase genes, play critical roles in cellular responses and are implicated in various signaling pathways. Moreover, PTPs are dysregulated and involved in various cellular processes in numerous cancers, including HCC. Kinases and phosphatases are coordinators that modulate cell activities and regulate signaling responses. There are multiple interacting signaling networks, and coordination of these signaling networks in response to a stimulus determines the physiological outcome. Numerous issues, such as drug resistance and inflammatory reactions in the tumor microenvironment, are implicated in cancer progression, and the role of PTPs in these processes has not been well elucidated. Therefore, the present review focused on discussing the relationship of PTPs with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC. AD - Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C. Division of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan, R.O.C. Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C. Department of Medical Laboratory Science, College of Medicine, I‑Shou University, Kaohsiung 82445, Taiwan, R.O.C. Aging and Diseases Prevention Research Center, Fooyin University, Kaohsiung 83102, Taiwan, R.O.C. AU - Chen,Yi-Li AU - Hsieh,Ching-Chuan AU - Chu,Pei-Ming AU - Chen,Jing-Yi AU - Huang,Yu-Chun AU - Chen,Cheng-Yi DA - 2023/03/01 DO - 10.3892/or.2023.8485 IS - 3 JO - Oncol Rep KW - protein tyrosine phosphatases hepatocellular carcinoma drug resistance inflammation PY - 2023 SN - 1021-335X 1791-2431 SP - 48 ST - Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review) T2 - Oncology Reports TI - Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review) UR - https://doi.org/10.3892/or.2023.8485 VL - 49 ER -