TY - JOUR AB - The effects of retinoic acid (RA) on cell replication, fibronectin and laminin synthesis, integrin expression and haptotactic migration of three mesothelioma cell cultures of different histotype, one epithelioid, one fibromatous and one biphasic, were evaluated. Cell growth was not affected by RA, while RA treatment decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin; on the contrary, the expression of some integrins was not significantly modified by RA. These data indicate that RA may lead to a decrease of mesothelioma cell local invasion; this can correlate with a modification induced by RA on mesothelioma tumor progression in vivo. AD - Dipartimento Medicina Sperimentale e Patologia, I-00161 Roma, Italy null AU - Scarpa,Susanna AU - Giuffrida,Anna AU - Palumbo,Camilla AU - Coletti,Anna AU - Cerrito,Maria,Grazia AU - Vasaturo,Fortunata AU - Sinibaldi,Paola AU - Simonelli,Lucilla AU - Procopio,Antonio AU - Modesti,Andrea DA - 2002/01/01 DO - 10.3892/or.9.1.205 EP - 209 IS - 1 JO - Oncol Rep PY - 2002 SN - 1021-335X 1791-2431 SP - 205 ST - Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro T2 - Oncology Reports TI - Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro UR - https://doi.org/10.3892/or.9.1.205 VL - 9 ER -