TY - JOUR AB - Right ventricle/ventricular (RV) failure induced by sustained pressure overload is a major contributor to morbidity and mortality in several cardiopulmonary disorders. Reliable and reproducible animal models of RV failure are crucial for investigating disease mechanisms and the effects of potential therapeutic strategies. In the present study, in order to establish a rat model of acute RV failure, the hemodynamic characteristics of the RV and the carotid artery in rats with varying degrees of pulmonary artery banding (PAB) were analyzed. For this purpose, rats were divided into 6 groups as follows: The control (0%), PAB (1‑30%), PAB (31‑60%), PAB (61‑70%), PAB (71‑80%), or PAB (100%). RV pressure (RVP) was measured using right heart catheterization when the pulmonary artery was ligated. The results revealed that the RVP gradually increased with the increasing degrees of banding; however, when the occlusion level exceeded 70%, a high‑pressure state was only maintained for a few minutes or seconds, and the RVP then rapidly declined to below normal pressure levels, which was particularly evident in the PAB (100%) group. On the whole, the present study demonstrates that RVP responds differently to changes in the occlusion level, and that >70% ligation is a successful model of acute right heart failure. These results may have important implications for therapeutic strategies to prevent acute right heart failure. AD - Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200030, P.R. China AU - Song,Jiyang AU - Shen,Shutong AU - Wei,Ying AU - Li,Wenli AU - Wang,Nan DA - 2021/11/01 DO - 10.3892/wasj.2021.125 IS - 6 JO - World Acad Sci J KW - hemodynamic characteristics right ventricular hypertrophy right ventricular failure pulmonary gradient pulmonary artery banding rats PY - 2021 SN - 2632-2900 2632-2919 SP - 54 ST - Hemodynamic characteristics of the right ventricle following gradient pulmonary artery banding in rats T2 - World Academy of Sciences Journal TI - Hemodynamic characteristics of the right ventricle following gradient pulmonary artery banding in rats UR - https://doi.org/10.3892/wasj.2021.125 VL - 3 ER -