Journal Articles

Antibiotic & Drug Discovery and Development

Lead Editor:

    Professor Vijaya Anand
    Bharathiar University

A long and exhausting screening of compounds that can act as modulators of a therapeutic target is required for drug discovery and development. This special issue will include articles and research on the "discovery and development of potential drugs" with a focus on proteins / enzymes as therapeutic targets that may be involved in the onset and progression of disease or a specific human infection. The journals in this special issue will present the most recent advances drug screening methods for identifying chemicals or natural compounds capable of effectively interacting with a target. In order to develop a drug suitable for clinical trials, therapy must be used. New strategies for drug discovery, design, and synthesis will be described in research articles. Chemical biology, also known as "chemistry-initiated biology," is an interdisciplinary field of study. Because all biological processes are the result of chemical events, chemical approaches can be used to comprehend and, in some cases, manipulate biological events. This rapidly expanding field of study will continue to open up new opportunities for future drug discovery and medical applications. The current special issue focuses on fundamental aspects of chemical biology: the development and application of "chemical probes" and "chemical tools" for the analysis and comprehension of biological events and disease states. significant in terms of paving the way for medical innovations and diagnostics The issue will include communications, full articles, and targeted reviews that will present recent advances in chemical biology in Asia. Over the last decade, antimicrobial resistance (AMR) has gotten a lot of attention throughout the world. The absence of antibiotics in the clinical pipeline is due to the lack of financial incentives for commercial development of antibiotics. As evidenced by the present COVID-19 problem, this has resulted in a perilous situation in which the widespread proliferation of highly resistant strains could jeopardise the global health system's viability. While a number of nonantibiotic alternative antimicrobial techniques show promise, it's hard to see how they'll be able to eliminate the need for new antibiotics in the near future. Small molecule inhibitors and probes, for example, hold a unique place in the arsenal of techniques for studying biological systems. They can be used to characterise the mechanistic and structural properties of individual proteins, as well as to interrogate the proteome of an entire organism. Chemical tools enable reversible, dose- and time-dependent interventions in a way that few other techniques can, as well as permanent labelling experiments in intact cells. They are effective tools for target identification and validation studies, and they can also serve as chemical starting points for antibiotic discovery. This Special Issue intends to highlight recent advances examples of chemical tools to address this challenge.

Submission deadline: 03/09/2022