Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers

  • Authors:
    • Min K. Maw
    • Jiro Fujimoto
    • Teruhiko Tamaya
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/etm_00000055
  • Pages: 351-356
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Abstract

The inhibitor of DNA binding (ID)-1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been found to be involved in multiple cellular functions. In the present study, ID-1 histoscores and mRNA levels were both significantly (p<0.05) increased in uterine endometrial cancers according to clinical stage, histological grade and depth of myometrial invasion. Furthermore, the 60-month survival rate of the 25 patients with high ID-1 was poor (52%), while that of the other 25 patients with low ID-1 was significantly higher (80%) (p<0.05). ID-1 histoscores and mRNA levels significantly (p<0.0001) correlated with microvessel counts in uterine endometrial cancers. Therefore, ID-1 acts on tumor advancement via angiogenic activity and can be considered a candidate prognostic indicator in uterine endometrial cancers.
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March-April 2010
Volume 1 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Maw MK, Fujimoto J and Tamaya T: Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers . Exp Ther Med 1: 351-356, 2010
APA
Maw, M.K., Fujimoto, J., & Tamaya, T. (2010). Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers . Experimental and Therapeutic Medicine, 1, 351-356. https://doi.org/10.3892/etm_00000055
MLA
Maw, M. K., Fujimoto, J., Tamaya, T."Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers ". Experimental and Therapeutic Medicine 1.2 (2010): 351-356.
Chicago
Maw, M. K., Fujimoto, J., Tamaya, T."Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 351-356. https://doi.org/10.3892/etm_00000055