Open Access

The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study

  • Authors:
    • Pinglin Yang
    • Xiong Guo
    • Xijing He
    • Quanjin Zang
    • Guoyu Wang
    • Peng Xu
    • Weizhuo Wang
  • View Affiliations

  • Published online on: May 19, 2016     https://doi.org/10.3892/etm.2016.3364
  • Pages: 739-745
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to determine whether hyaluronic acid (HA) or physical therapy agents (PTA) can improve functional parameters in patients with knee Kashin‑Beck disease (KBD). For 2 years, patients (n=55) were treated with HA weekly for 5 weeks, then received 6th and 7th injections on the 3rd and 6th month, respectively, for 7 injections in total. Patients (n=53) were treated with PTA five times a week for 3 weeks every month for 6 months. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). Trial registration, ChiCTR-TRC-12002189 (http://www.chictr.org/). During the study, following treatment interruption, pain increased in the PTA group (from a mean value of 85.7±83.8 mm at month 12 to 145.2±128.8 mm at month 18 and 201.3±150.5 mm at month 24), while it remained stable in the HA group (from a mean value of 80.7±70.6 mm at month 12 to 90.1±95.2 mm at month 18 and 82.6±85.3 mm at month  24), with a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). Joint stiffness, physical function and total WOMAC showed the same trend as pain. The global efficacy judgments by the patients and the investigators showed a statistically significant difference in favor of HA at month 18 (P<0.05) and month 24 (P<0.05). In conclusion, although all the patients improved in terms of pain and function, HA was superior to PTA alone for pain relief and lasting effect.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang P, Guo X, He X, Zang Q, Wang G, Xu P and Wang W: The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. Exp Ther Med 12: 739-745, 2016
APA
Yang, P., Guo, X., He, X., Zang, Q., Wang, G., Xu, P., & Wang, W. (2016). The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study. Experimental and Therapeutic Medicine, 12, 739-745. https://doi.org/10.3892/etm.2016.3364
MLA
Yang, P., Guo, X., He, X., Zang, Q., Wang, G., Xu, P., Wang, W."The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study". Experimental and Therapeutic Medicine 12.2 (2016): 739-745.
Chicago
Yang, P., Guo, X., He, X., Zang, Q., Wang, G., Xu, P., Wang, W."The efficacy and safety of intra-articular injection of hyaluronic acid in the knee and physical therapy agents to treat Kashin-Beck disease: A prospective interventional study". Experimental and Therapeutic Medicine 12, no. 2 (2016): 739-745. https://doi.org/10.3892/etm.2016.3364