Open Access

Burn wound healing properties of asiaticoside and madecassoside

  • Authors:
    • Qiang Hou
    • Ming Li
    • Yan‑Hua Lu
    • Dong‑Hong Liu
    • Cheng‑Cun Li
  • View Affiliations

  • Published online on: June 16, 2016     https://doi.org/10.3892/etm.2016.3459
  • Pages: 1269-1274
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo‑vascularization, granulation, re-epithelialization, inflammation and wound contraction. Various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. The aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (AE) and madecassoside (MA), which are found in the herb Centella asiatica. The cytotoxic nature of the AE and MA were inspected and were confirmed to be non‑toxic up to 500 ppm. The compounds AE and MA increased monocyte chemoattractant protein‑1 production, but caused no significant effect on vascular endothelial growth factor production. In addition, an in vivo animal burn model was employed to represent the features of burn wound healing. Hence, the present results warrant the further investigation of C. asiatica extracts for use in burn healing.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Hou Q, Li M, Lu YH, Liu DH and Li CC: Burn wound healing properties of asiaticoside and madecassoside. Exp Ther Med 12: 1269-1274, 2016
APA
Hou, Q., Li, M., Lu, Y., Liu, D., & Li, C. (2016). Burn wound healing properties of asiaticoside and madecassoside. Experimental and Therapeutic Medicine, 12, 1269-1274. https://doi.org/10.3892/etm.2016.3459
MLA
Hou, Q., Li, M., Lu, Y., Liu, D., Li, C."Burn wound healing properties of asiaticoside and madecassoside". Experimental and Therapeutic Medicine 12.3 (2016): 1269-1274.
Chicago
Hou, Q., Li, M., Lu, Y., Liu, D., Li, C."Burn wound healing properties of asiaticoside and madecassoside". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1269-1274. https://doi.org/10.3892/etm.2016.3459