Open Access

Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm

  • Authors:
    • Wanpin Nie
    • Yan Wang
    • Kai Yao
    • Zheng Wang
    • Hao Wu
  • View Affiliations

  • Published online on: June 17, 2016     https://doi.org/10.3892/etm.2016.3466
  • Pages: 1412-1418
  • Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Open surgical repair (OSR) is a conventional surgical method used in the repair a ruptured abdominal aortic aneurysm (AAA); however, OSR results in high perioperative mortality rates. The level of serum angiotensin‑converting enzyme 2 (ACE2) has been reported to be an independent risk factor for postoperative in‑hospital mortality following major cardiopulmonary surgery. In the present study, the association of serum ACE2 levels with postoperative in‑hospital mortality was investigated in patients undergoing OSR for ruptured AAA. The study enrolled 84 consecutive patients underwent OSR for ruptured AAA and were subsequently treated in the intensive care unit. Patients who succumbed postoperatively during hospitalization were defined as non‑survivors. Serum ACE2 levels were measured in all patients prior to and following the surgery using ELISA kits. The results indicated that non‑survivors showed significantly lower mean preoperative and postoperative serum ACE2 levels when compared with those in survivors. Multivariate logistic regression analysis also showed that, subsequent to adjusting for potential confounders, the serum ACE2 level on preoperative day 1 showed a significant negative association with the postoperative in‑hospital mortality. This was confirmed by multivariate hazard ratio analysis, which showed that, subsequent to adjusting for the various potential confounders, the risk of postoperative in‑hospital mortality remained significantly higher in the two lowest serum ACE2 level quartiles compared with that in the highest quartile on preoperative day 1. In conclusion, the present study provided the first evidence supporting that the serum ACE2 level is an independent risk factor for the in-hospital mortality following OSR for ruptured AAA. Furthermore, low serum ACE2 levels on preoperative day 1 were found to be associated with increased postoperative in‑hospital mortality. Therefore, the serum ACE2 level on preoperative day 1 may be a potential biomarker or prognostic factor for in-hospital mortality following OSR for ruptured AAA.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Nie W, Wang Y, Yao K, Wang Z and Wu H: Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm. Exp Ther Med 12: 1412-1418, 2016
APA
Nie, W., Wang, Y., Yao, K., Wang, Z., & Wu, H. (2016). Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm. Experimental and Therapeutic Medicine, 12, 1412-1418. https://doi.org/10.3892/etm.2016.3466
MLA
Nie, W., Wang, Y., Yao, K., Wang, Z., Wu, H."Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm". Experimental and Therapeutic Medicine 12.3 (2016): 1412-1418.
Chicago
Nie, W., Wang, Y., Yao, K., Wang, Z., Wu, H."Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1412-1418. https://doi.org/10.3892/etm.2016.3466