Open Access

High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome

  • Authors:
    • Sun‑Young Lee
    • Jong‑Hyun Kim
    • Dong‑Hyu Cho
  • View Affiliations

  • Published online on: June 15, 2016     https://doi.org/10.3892/etm.2016.3458
  • Pages: 1435-1439
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize PAMS. The most common symptoms of PAMS include pain associated with continuous oral ulceration and resistance to pharmacological treatment. The present study reports the case of a 42-year-old female patient who was admitted with an 8‑month history of erosive skin lesions within the trunk region, oral mucosa and vaginal mucosa. The patient was diagnosed with PAMS based on computed tomography scans and histological analyses of the lesions. The lymphoid hyperplasia in the retroperitoneum and lesions in the vaginal mucosa and trunk area were improved following pharmacological treatment and resection of the lymph node showing hyperplasia. However, the oral lesion was treated with intraluminal brachytherapy due to its resistance to long‑term pharmacological treatment. The majority of the lesions were improved following treatment, in the absence of any severe side effects. In addition, neither worsening nor progression of the oral lesion was observed during the 4-year follow-up period.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lee SY, Kim JH and Cho DH: High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome. Exp Ther Med 12: 1435-1439, 2016
APA
Lee, S., Kim, J., & Cho, D. (2016). High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome. Experimental and Therapeutic Medicine, 12, 1435-1439. https://doi.org/10.3892/etm.2016.3458
MLA
Lee, S., Kim, J., Cho, D."High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome". Experimental and Therapeutic Medicine 12.3 (2016): 1435-1439.
Chicago
Lee, S., Kim, J., Cho, D."High-dose-rate intraluminal brachytherapy for paraneoplastic autoimmune multiorgan syndrome". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1435-1439. https://doi.org/10.3892/etm.2016.3458