Xuebijing injection alleviates cytokine‑induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1

  • Authors:
    • Ailin Li
    • Jing Li
    • Yuhua Bao
    • Dingshan Yuan
    • Zhongwei Huang
  • View Affiliations

  • Published online on: June 24, 2016     https://doi.org/10.3892/etm.2016.3476
  • Pages: 1531-1536
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Abstract

Dysregulation of inflammatory cytokines and liver injury are associated with the pathogenesis of sepsis. Xuebijing injection, a Chinese herbal medicine, has been used in the treatment of sepsis and can contribute to the improvement of patients' health. However, the underlying molecular mechanisms are not yet clearly illuminated. In the present study, a septic rat model with liver injury was established by the cecal ligation and puncture (CLP) method. Histological alterations to the liver, activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), levels of inflammatory cytokine secretion and the expression of suppressors of cytokine signaling 1 (SOCS‑1) in the CLP model rats with and without Xuebijing treatment were determined. The results showed that Xuebijing injection ameliorated the pathological changes in liver tissues caused by sepsis, and reduced the sepsis‑induced elevation in serum ALT and AST levels. Furthermore, Xuebijing injection markedly downregulated the expression of tumor necrosis factor α and interleukin (IL)‑6, and upregulated the expression of IL‑10. More importantly, SOCS1 expression levels at the protein and mRNA levels were further increased by Xuebijing. These findings demonstrate that Xuebijing injection can significantly alleviate liver injury in CLP‑induced septic rats via the regulation of inflammatory cytokine secretion and the promotion of SOCS1 expression. The protective effects of Xuebijing injection suggest its therapeutic potential in the treatment of CLP‑induced liver injury.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li A, Li J, Bao Y, Yuan D and Huang Z: Xuebijing injection alleviates cytokine‑induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1. Exp Ther Med 12: 1531-1536, 2016
APA
Li, A., Li, J., Bao, Y., Yuan, D., & Huang, Z. (2016). Xuebijing injection alleviates cytokine‑induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1. Experimental and Therapeutic Medicine, 12, 1531-1536. https://doi.org/10.3892/etm.2016.3476
MLA
Li, A., Li, J., Bao, Y., Yuan, D., Huang, Z."Xuebijing injection alleviates cytokine‑induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1". Experimental and Therapeutic Medicine 12.3 (2016): 1531-1536.
Chicago
Li, A., Li, J., Bao, Y., Yuan, D., Huang, Z."Xuebijing injection alleviates cytokine‑induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1531-1536. https://doi.org/10.3892/etm.2016.3476