Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1

  • Authors:
    • Guizuo Wang
    • Yang Song
    • Wei Feng
    • Lu Liu
    • Yanting Zhu
    • Xinming Xie
    • Yilin Pan
    • Rui Ke
    • Shaojun Li
    • Fangwei Li
    • Lan Yang
    • Manxiang Li
  • View Affiliations

  • Published online on: June 17, 2016     https://doi.org/10.3892/etm.2016.3465
  • Pages: 1551-1555
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Abstract

Evidence suggests that an imbalance between oxidation and antioxidation is involved in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Activation of AMP-activated protein kinase (AMPK) has been shown to inhibit the occurrence of ALI/ARDS. However, it is unknown whether activation of AMPK benefits ALI/ARDS by restoration of the oxidant and antioxidant balance, and which mechanisms are responsible for this process. The present study aimed to address these issues. Lipopolysaccharide (LPS) induced pronounced pathological changes of ALI in mice; these were accompanied by elevated production of malondialdehyde (MDA) and decreased activity of superoxide dismutase (SOD) compared with control mice. Prior treatment of mice with the AMPK agonist metformin significantly suppressed the LPS‑induced development of ALI, reduced the elevation of MDA and increased the activity of SOD. Further analysis indicated that activation of AMPK also stimulated the protein expression of peroxisome proliferator‑activated receptor γ coactivator 1α (PGC1α) and superoxide dismutase 1 (SOD1). This study suggests that activation of AMPK by metformin inhibits oxidative stress by upregulation of PGC1α and SOD1, thereby suppressing the development of ALI/ARDS, and has potential value in the clinical treatment of such conditions.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang G, Song Y, Feng W, Liu L, Zhu Y, Xie X, Pan Y, Ke R, Li S, Li F, Li F, et al: Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Exp Ther Med 12: 1551-1555, 2016
APA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X. ... Li, M. (2016). Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1. Experimental and Therapeutic Medicine, 12, 1551-1555. https://doi.org/10.3892/etm.2016.3465
MLA
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12.3 (2016): 1551-1555.
Chicago
Wang, G., Song, Y., Feng, W., Liu, L., Zhu, Y., Xie, X., Pan, Y., Ke, R., Li, S., Li, F., Yang, L., Li, M."Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1551-1555. https://doi.org/10.3892/etm.2016.3465