Open Access

Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review)

  • Authors:
    • Qingmei Nie
    • Baohua Su
    • Jianping Wei
  • View Affiliations

  • Published online on: August 29, 2016     https://doi.org/10.3892/etm.2016.3628
  • Pages: 2400-2404
  • Copyright: © Nie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.8% of pregnant women. Prescription of antiepileptic drugs (AEDs) to pregnant women with epilepsy requires monitoring and maintaining a balance between limiting seizures and decreasing fetal exposure to the potential teratogenic effects. AEDs are also commonly used for psychiatric disorders, pain disorders, and migraines. The types of malformations that can result in fetuses exposed to AEDs include minor anomalies, major congenital malformations, intrauterine growth retardation, cognitive dysfunction, low IQ, microcephaly, and infant mortality. In the present review, we analyzed and summarized the current understanding of neurological development in fetuses that are exposed to various AEDs administered to pregnant epileptic women.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nie Q, Su B and Wei J: Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review). Exp Ther Med 12: 2400-2404, 2016
APA
Nie, Q., Su, B., & Wei, J. (2016). Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review). Experimental and Therapeutic Medicine, 12, 2400-2404. https://doi.org/10.3892/etm.2016.3628
MLA
Nie, Q., Su, B., Wei, J."Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review)". Experimental and Therapeutic Medicine 12.4 (2016): 2400-2404.
Chicago
Nie, Q., Su, B., Wei, J."Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review)". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2400-2404. https://doi.org/10.3892/etm.2016.3628