Open Access

Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure

  • Authors:
    • Feng Zhou
    • Peichen Zhang
    • Xiaoxi Chen
    • Jingyi Yan
    • Jiangao Yao
    • Zhen Yu
    • Xiaolei Chen
  • View Affiliations

  • Published online on: August 31, 2016     https://doi.org/10.3892/etm.2016.3639
  • Pages: 2563-2567
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ginsenoside Rb1 (GRb1), which is one of the main ingredients derived from Panax ginseng, has been widely used to treat various gastrointestinal disorders. The present study aimed to determine whether GRb1 was able to prevent intestinal mucosal barrier damage in rats following peritoneal air exposure for 3 h. GRb1 (5, 10, and 20 mg/kg) was orally administrated via gavage four times prior to and following surgery. Blood and terminal ileum were sampled 24 h following surgery. Levels of serum D‑lactate (D‑LA) were detected using an enzyme‑linked immunosorbent assay kit. Intestinal permeability was assessed by determining the intestinal clearance of fluorescein isothiocyanate-dextran (FD4). Activity of intestinal myeloperoxidase was measured to assess intestinal inflammation, and intestinal histopathology was assessed by light microscopy. The results showed that GRb1 reduced the level of serum D‑LA, intestinal clearance of FD4, and the activity of intestinal myeloperoxidase. Intestinal edema and inflammation were also ameliorated by GRb1, and the Chiu's scores employed for assessing intestinal mucosal damage were also reduced in the GRb1‑treated peritoneal air exposure group. In addition, GRb1 induced a significant difference at 10 and 20 mg/kg, indicating a dose‑dependent effect. The results of the present study suggest that GRb1 may be able to protect the intestinal mucosal barrier against damage induced by peritoneal air exposure, which may be associated with its anti-inflammatory action.

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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou F, Zhang P, Chen X, Yan J, Yao J, Yu Z and Chen X: Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure. Exp Ther Med 12: 2563-2567, 2016
APA
Zhou, F., Zhang, P., Chen, X., Yan, J., Yao, J., Yu, Z., & Chen, X. (2016). Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure. Experimental and Therapeutic Medicine, 12, 2563-2567. https://doi.org/10.3892/etm.2016.3639
MLA
Zhou, F., Zhang, P., Chen, X., Yan, J., Yao, J., Yu, Z., Chen, X."Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure". Experimental and Therapeutic Medicine 12.4 (2016): 2563-2567.
Chicago
Zhou, F., Zhang, P., Chen, X., Yan, J., Yao, J., Yu, Z., Chen, X."Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2563-2567. https://doi.org/10.3892/etm.2016.3639