Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

  • Authors:
    • Yan‑Mei Xu
    • Guo‑Hua Ding
    • Jie Huang
    • Yan Xiong
  • View Affiliations

  • Published online on: September 6, 2016     https://doi.org/10.3892/etm.2016.3674
  • Pages: 2741-2746
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti‑inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF‑α and IL‑6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase‑3, B‑cell lymphoma 2 (Bcl‑2) and p38 mitogen‑activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinone IIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF‑α and IL‑6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase‑3 and p38 MAPK protein expression levels in I/RIRI rats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase‑3 and p38 MAPK.
View Figures
View References

Related Articles

Journal Cover

October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu YM, Ding GH, Huang J and Xiong Y: Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Exp Ther Med 12: 2741-2746, 2016
APA
Xu, Y., Ding, G., Huang, J., & Xiong, Y. (2016). Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Experimental and Therapeutic Medicine, 12, 2741-2746. https://doi.org/10.3892/etm.2016.3674
MLA
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12.4 (2016): 2741-2746.
Chicago
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2741-2746. https://doi.org/10.3892/etm.2016.3674