Open Access

Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report

  • Authors:
    • Shou‑Chen Ren
    • Bao‑Qin Gao
    • Wei‑Li Yang
    • Wei‑Xin Feng
    • Jian Xu
    • Shao‑Wu Li
    • Yong‑Jun Wang
  • View Affiliations

  • Published online on: October 3, 2016     https://doi.org/10.3892/etm.2016.3769
  • Pages: 3195-3200
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol treatment was thus administrated. After 2 months of treatment, the patient's thyroid function returned to normal and the neurological symptoms improved gradually. At the same time, the activities of vWF and FVIII were depressed. During the 20‑month follow‑up, information regarding the neurological symptoms, cerebrovascular imaging, thyroid function, thyroid autoantibodies and coagulation parameters was collected. High levels of thyroid autoantibodies persisted throughout the follow‑up period, while other coagulation parameters remained in the normal range. In conclusion, considering the vital role of vWF and FVIII in vascular diseases, it is hypothesized that these two factors may serve an important role in the occurrence of GD associated with MMD.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ren SC, Gao BQ, Yang WL, Feng WX, Xu J, Li SW and Wang YJ: Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report. Exp Ther Med 12: 3195-3200, 2016
APA
Ren, S., Gao, B., Yang, W., Feng, W., Xu, J., Li, S., & Wang, Y. (2016). Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report. Experimental and Therapeutic Medicine, 12, 3195-3200. https://doi.org/10.3892/etm.2016.3769
MLA
Ren, S., Gao, B., Yang, W., Feng, W., Xu, J., Li, S., Wang, Y."Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report". Experimental and Therapeutic Medicine 12.5 (2016): 3195-3200.
Chicago
Ren, S., Gao, B., Yang, W., Feng, W., Xu, J., Li, S., Wang, Y."Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3195-3200. https://doi.org/10.3892/etm.2016.3769