Open Access

Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients

  • Authors:
    • Wei‑Xia Zhang
    • Cheng‑Yan Ma
    • Jian‑Guo Zhang
    • Feng He
    • Qing‑Min Liu
    • Aibin Cheng
    • Tiejun Liu
    • Junwei Zhang
    • Jianjun Wang
    • Xuan Bu
    • Yuxi Xie
    • Zengli Diao
    • Jing Bai
  • View Affiliations

  • Published online on: October 3, 2016     https://doi.org/10.3892/etm.2016.3763
  • Pages: 3287-3293
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the effects of cytomegalovirus (CMV) infection on the prognosis of inflammatory bowel disease (IBD). Various databases were searched using a combination of keywords associated with CMV infection and IBD. Subsequent to the selection of relevant studies in line with strict inclusion and exclusion criteria, a meta‑analysis was conducted using the Stata 12.0 software. A total of 195 studies were initially retrieved, including 28 studies in Chinese and 167 in English. Following the exclusion of unsuitable studies, 7 cohort studies with 374 IBD patients were included in the meta‑analysis. The results of the present study identified significant differences between patients with and without CMV infection regarding the disease duration of IBD [standardized mean difference, ‑0.81; 95% confidence interval (CI), ‑1.19 to ‑0.43; P<0.001], the efficacy of corticosteroid therapy [relative risk (RR), 1.24; 95% CI, 1.02‑1.49; P=0.029], the colectomy rate (RR, 2.13; 95% CI, 1.03‑4.40; P=0.042) and the incidence of severe IBD (RR, 1.32; 95% CI, 1.04‑1.67; P=0.022). Considering the IBD onset area, patients with CMV infection may have higher susceptibility to pancolitis (RR, 1.31; 95% CI; 1.01‑1.72; P=0.045); however, no difference in susceptibility to left‑sided IBD was observed between patients with or without CMV infection (RR, 0.97; 95% CI, 0.72‑1.30; P=0.828). In conclusion, CMV infection may be associated with the disease duration, efficacy of corticosteroid therapy, colectomy rate, severe IBD incidence and disease location of IBD; thus, the presence of CMV infection may be considered as an important biomarker for determining the prognosis of IBD.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang WX, Ma CY, Zhang JG, He F, Liu QM, Cheng A, Liu T, Zhang J, Wang J, Bu X, Bu X, et al: Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients. Exp Ther Med 12: 3287-3293, 2016
APA
Zhang, W., Ma, C., Zhang, J., He, F., Liu, Q., Cheng, A. ... Bai, J. (2016). Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients. Experimental and Therapeutic Medicine, 12, 3287-3293. https://doi.org/10.3892/etm.2016.3763
MLA
Zhang, W., Ma, C., Zhang, J., He, F., Liu, Q., Cheng, A., Liu, T., Zhang, J., Wang, J., Bu, X., Xie, Y., Diao, Z., Bai, J."Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients". Experimental and Therapeutic Medicine 12.5 (2016): 3287-3293.
Chicago
Zhang, W., Ma, C., Zhang, J., He, F., Liu, Q., Cheng, A., Liu, T., Zhang, J., Wang, J., Bu, X., Xie, Y., Diao, Z., Bai, J."Effects of cytomegalovirus infection on the prognosis of inflammatory bowel disease patients". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3287-3293. https://doi.org/10.3892/etm.2016.3763