Open Access

β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro

  • Authors:
    • Masayoshi Yamaguchi
    • Robert M. Levy
  • View Affiliations

  • Published online on: October 18, 2016     https://doi.org/10.3892/etm.2016.3818
  • Pages: 3602-3606
  • Copyright: © Yamaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoporosis is induced by the reduction in bone mass through decreased osteoblastic osteogenesis and increased osteoclastic bone resorption, and it is associated with obesity and diabetes. Osteoblasts and adipocytes are derived from bone marrow mesenchymal stem cells. The prevention of osteoporosis is an important public health concern in aging populations. β‑caryophyllene, a component of various essential oils, is a selective agonist of the cannabinoid receptor type 2 and exerts cannabimimetic anti‑inflammatory effects in animals. The present study aimed to identify the effect of β-caryophyllene on adipogenesis, osteoblastic mineralization and osteoclastogenesis in mouse bone marrow cell cultures in vitro. Bone marrow cells obtained from mouse femoral tissues were cultured in the presence of β‑caryophyllene (0.1-100 µM) in vitro. The results revealed that β‑caryophyllene stimulated osteoblastic mineralization, and suppressed adipogenesis and osteoclastogenesis. Thus, β‑caryophyllene may be used as a therapeutic agent for the prevention and treatment of osteoporosis.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yamaguchi M and Yamaguchi M: β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro. Exp Ther Med 12: 3602-3606, 2016
APA
Yamaguchi, M., & Yamaguchi, M. (2016). β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro. Experimental and Therapeutic Medicine, 12, 3602-3606. https://doi.org/10.3892/etm.2016.3818
MLA
Yamaguchi, M., Levy, R. M."β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro". Experimental and Therapeutic Medicine 12.6 (2016): 3602-3606.
Chicago
Yamaguchi, M., Levy, R. M."β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3602-3606. https://doi.org/10.3892/etm.2016.3818