Open Access

Urinary neutrophil gelatinase-associated lipocalin is an early predictor of acute kidney injury in premature infants

  • Authors:
    • Ryota Kuribayashi
    • Hiroshi Suzumura
    • Toshimi Sairenchi
    • Yoshiyuki Watabe
    • Yayoi Tsuboi
    • George Imataka
    • Hidemitsu Kurosawa
    • Osamu Arisaka
  • View Affiliations

  • Published online on: October 25, 2016     https://doi.org/10.3892/etm.2016.3837
  • Pages: 3706-3710
  • Copyright: © Kuribayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is produced in response to tubular epithelial injury and is a biomarker of tubulointerstitial injury. The aim of the present study was to examine whether acute kidney injury (AKI) could be predicted by measuring uNGAL in very low‑birth weight (VLBW) infants. Forty VLBW infants with birthweight below 1,500 g were enrolled in the present study. uNGAL and serum creatinine (sCre) were measured daily from postnatal days 0 to 8. Infants with sCre ≥1.2 mg/dl were diagnosed with AKI. The relationship of uNGAL with sCre was measured on the day after uNGAL measurement (next‑day sCre) was examined. The results showed that 16 infants had sCre ≥1.2 mg/dl in this period. Logistic regression analysis revealed that uNGAL on postnatal days 2, 3, 4, 5 and 6 was correlated with next‑day sCre (P<0.05). uNGAL corrected by urinary Cre (uCre) (uNGAL/uCre) was only correlated with an increase in next-day sCre on postnatal days 5 and 6 (P<0.05). For the logistic analysis, subjects with high and low uNGAL levels based on the median value for each day, uNGAL on postnatal days 2, 3 and 6 in the high uNGAL group was correlated with an increase in next‑day sCre. Thus, AKI may be predicted by measuring uNGAL in VLBW infants. This measurement was non-invasive, and is potentially useful for the evaluation of renal function in VLBW infants.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kuribayashi R, Suzumura H, Sairenchi T, Watabe Y, Tsuboi Y, Imataka G, Kurosawa H and Arisaka O: Urinary neutrophil gelatinase-associated lipocalin is an early predictor of acute kidney injury in premature infants. Exp Ther Med 12: 3706-3710, 2016
APA
Kuribayashi, R., Suzumura, H., Sairenchi, T., Watabe, Y., Tsuboi, Y., Imataka, G. ... Arisaka, O. (2016). Urinary neutrophil gelatinase-associated lipocalin is an early predictor of acute kidney injury in premature infants. Experimental and Therapeutic Medicine, 12, 3706-3710. https://doi.org/10.3892/etm.2016.3837
MLA
Kuribayashi, R., Suzumura, H., Sairenchi, T., Watabe, Y., Tsuboi, Y., Imataka, G., Kurosawa, H., Arisaka, O."Urinary neutrophil gelatinase-associated lipocalin is an early predictor of acute kidney injury in premature infants". Experimental and Therapeutic Medicine 12.6 (2016): 3706-3710.
Chicago
Kuribayashi, R., Suzumura, H., Sairenchi, T., Watabe, Y., Tsuboi, Y., Imataka, G., Kurosawa, H., Arisaka, O."Urinary neutrophil gelatinase-associated lipocalin is an early predictor of acute kidney injury in premature infants". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3706-3710. https://doi.org/10.3892/etm.2016.3837