Open Access

Protective approaches against myocardial ischemia reperfusion injury (Review)

  • Authors:
    • Xianchi Li
    • Min Liu
    • Rongrong Sun
    • Yi Zeng
    • Shuang Chen
    • Peiying Zhang
  • View Affiliations

  • Published online on: November 7, 2016     https://doi.org/10.3892/etm.2016.3877
  • Pages: 3823-3829
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myocardial ischemia-reperfusion is the leading cause for the events of cardiovascular disease, and is considered as a major contributor to the morbidity and mortality associated with coronary occlusion. The myocardial damage caused by ischemia‑reperfusion injury constitutes the primary pathological manifestation of coronary artery disease. It results from the interaction between the substances that accumulate during ischemia and those that are delivered on reperfusion. The level of this damage can range from a small insult resulting in limited myocardial damage to a large injury culminating in myocyte death. Importantly, major ischemia‑reperfusion injury to the heart can result in permanent disability or death. Given the worldwide prevalence of coronary artery disease, developing a strategy to provide cardioprotection against ischemia‑reperfusion‑induced damage is of great importance. Currently, the treatment of reperfusion injury following ischemia is primarily supportive, since no specific target‑oriented therapy has been validated thus far. Nevertheless, therapeutic approaches to protect against myocardial ischemia‑reperfusion injury remain an active area of investigation given the detrimental effects of this phenomenon.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Liu M, Sun R, Zeng Y, Chen S and Zhang P: Protective approaches against myocardial ischemia reperfusion injury (Review). Exp Ther Med 12: 3823-3829, 2016
APA
Li, X., Liu, M., Sun, R., Zeng, Y., Chen, S., & Zhang, P. (2016). Protective approaches against myocardial ischemia reperfusion injury (Review). Experimental and Therapeutic Medicine, 12, 3823-3829. https://doi.org/10.3892/etm.2016.3877
MLA
Li, X., Liu, M., Sun, R., Zeng, Y., Chen, S., Zhang, P."Protective approaches against myocardial ischemia reperfusion injury (Review)". Experimental and Therapeutic Medicine 12.6 (2016): 3823-3829.
Chicago
Li, X., Liu, M., Sun, R., Zeng, Y., Chen, S., Zhang, P."Protective approaches against myocardial ischemia reperfusion injury (Review)". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3823-3829. https://doi.org/10.3892/etm.2016.3877