Open Access

CT-guided 125I seed implantation for inoperable retroperitoneal sarcoma: A technique for delivery of local tumor brachytherapy

  • Authors:
    • Biao Yang
    • Wen‑Hao Guo
    • Ting Lan
    • Fang Yuan
    • Guan‑Jian Liu
    • Rui‑Yu Zan
    • Xin You
    • Qiao‑Yue Tan
    • Zheng‑Yin Liao
  • View Affiliations

  • Published online on: November 14, 2016     https://doi.org/10.3892/etm.2016.3897
  • Pages: 3843-3850
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Radical surgery is currently the first treatment of choice for retroperitoneal soft tissue sarcoma (RSTS). However, the prognosis of RSTS remains poor due to ineffective local control and a high incidence of metastasis after surgical resection. Brachytherapy has been shown to safely provide local radiotherapy for numerous types of cancer when used alone or in combination with surgical resection, but has not been well characterized in the management of RSTS. The aim of this study was to evaluate CT‑guided 125I seed implantation for local control and pain relief in the treatment of inoperable RSTS. A total of 23 patients with RSTS were treated with 125I implantation. Pain was assessed using a visual analog scale. Other endpoints were evaluated via computed tomography scan or phone call/e‑mail records. The occurrence of complications was assessed preoperatively (baseline) and during postoperatively follow‑up or until patient succumbed. All patients were successfully treated with 125I implantation. A mean number of 70.87 radioactive seeds were applied in each patient. During the follow‑up, two patients were unaccounted for, local recurrence occurred in three patients, five succumbed and complications were observed in sixteen. The patient's VAS score changed from 7.4 preoperatively to 7.6, 2.3, 2.0, 1.2, 1.5, 1.4 and 2.5 at 24 h, 1, 3, 6, 12, 24 and 36 months after the procedure, respectively. Good local control and significant pain relief after 125I seed implantation was observed in patients with inoperable RSTS. Thus, the present results suggest that this method could be an effective treatment option for patients with inoperable RSTS.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang B, Guo WH, Lan T, Yuan F, Liu GJ, Zan RY, You X, Tan QY and Liao ZY: CT-guided 125I seed implantation for inoperable retroperitoneal sarcoma: A technique for delivery of local tumor brachytherapy. Exp Ther Med 12: 3843-3850, 2016
APA
Yang, B., Guo, W., Lan, T., Yuan, F., Liu, G., Zan, R. ... Liao, Z. (2016). CT-guided 125I seed implantation for inoperable retroperitoneal sarcoma: A technique for delivery of local tumor brachytherapy. Experimental and Therapeutic Medicine, 12, 3843-3850. https://doi.org/10.3892/etm.2016.3897
MLA
Yang, B., Guo, W., Lan, T., Yuan, F., Liu, G., Zan, R., You, X., Tan, Q., Liao, Z."CT-guided 125I seed implantation for inoperable retroperitoneal sarcoma: A technique for delivery of local tumor brachytherapy". Experimental and Therapeutic Medicine 12.6 (2016): 3843-3850.
Chicago
Yang, B., Guo, W., Lan, T., Yuan, F., Liu, G., Zan, R., You, X., Tan, Q., Liao, Z."CT-guided 125I seed implantation for inoperable retroperitoneal sarcoma: A technique for delivery of local tumor brachytherapy". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3843-3850. https://doi.org/10.3892/etm.2016.3897