Open Access

Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy

  • Authors:
    • Bin Lin
    • Hui Yu
    • Yongzhi He
    • Yang Xu
    • Wenbin Zhang
    • Chengwu Lu
    • Qingfang Ao
  • View Affiliations

  • Published online on: November 7, 2016     https://doi.org/10.3892/etm.2016.3878
  • Pages: 3917-3922
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nucleus pulposus (NP) has been suggested to trigger an autoimmune response if exposed to the immune system, which plays a key role in neuropathic pain. Therefore, appropriate suppression of inflammation is a key factor for treating the radiculopathy caused by intervertebral disk (IVD) degeneration. Resveratrol, a key component of red wine, has been suggested to exhibit anti‑inflammatory properties in vitro and in vivo. However, the effects of resveratrol on NP‑mediated pain in vivo have not been studied. The aim of the present study was to investigate whether resveratrol may be useful in treating NP‑mediated pain in an autologous NP model of radiculopathy. A total of 36 adult male Sprague‑Dawley rats were allocated randomly into sham (group I), saline‑treated (group II) and resveratrol‑treated (group III) groups. Animal behavior in response to non‑noxious mechanical stimulation with von Frey filaments was compared at days 0 (baseline), 3, 7, 14 and 21 following surgery. The expression of proinflammatory cytokines such as tumor necrosis factor α (TNF‑α) and interleukin‑1 (IL‑1) were assessed at days 7 and 14. The data showed that resveratrol exhibited an anti‑inflammatory effect on the expression of proinflammatory cytokines. Compared with group II, the expression of TNF‑α and IL‑1 was significantly decreased at each time point in group III. In addition, resveratrol significantly reduced pain behavior triggered by the application of NP tissue on the dorsal root ganglion for up to 14 days. These data suggest that resveratrol has potential for the treatment of NP‑mediated pain, indicating a potential clinical application.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lin B, Yu H, He Y, Xu Y, Zhang W, Lu C and Ao Q: Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy. Exp Ther Med 12: 3917-3922, 2016
APA
Lin, B., Yu, H., He, Y., Xu, Y., Zhang, W., Lu, C., & Ao, Q. (2016). Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy. Experimental and Therapeutic Medicine, 12, 3917-3922. https://doi.org/10.3892/etm.2016.3878
MLA
Lin, B., Yu, H., He, Y., Xu, Y., Zhang, W., Lu, C., Ao, Q."Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy". Experimental and Therapeutic Medicine 12.6 (2016): 3917-3922.
Chicago
Lin, B., Yu, H., He, Y., Xu, Y., Zhang, W., Lu, C., Ao, Q."Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3917-3922. https://doi.org/10.3892/etm.2016.3878