Open Access

Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study

  • Authors:
    • Hugo Leonid Gallardo‑Blanco
    • Jesus Zacarías Villarreal‑Perez
    • Ricardo Martin Cerda‑Flores
    • Andres Figueroa
    • Celia Nohemi Sanchez‑Dominguez
    • Juana Mercedes Gutierrez‑Valverde
    • Iris Carmen Torres‑Muñoz
    • Fernando Javier Lavalle‑Gonzalez
    • Esther Carlota Gallegos‑Cabriales
    • Laura Elia Martinez‑Garza
  • View Affiliations

  • Published online on: December 22, 2016     https://doi.org/10.3892/etm.2016.3990
  • Pages: 523-529
  • Copyright: © Gallardo‑Blanco et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low‑density lipoprotein (LDL), very LDL (VLDL), high‑density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was associated with LDL levels (P<0.05).

Related Articles

Journal Cover

February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gallardo‑Blanco HL, Villarreal‑Perez JZ, Cerda‑Flores RM, Figueroa A, Sanchez‑Dominguez CN, Gutierrez‑Valverde JM, Torres‑Muñoz IC, Lavalle‑Gonzalez FJ, Gallegos‑Cabriales EC, Martinez‑Garza LE, Martinez‑Garza LE, et al: Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Exp Ther Med 13: 523-529, 2017
APA
Gallardo‑Blanco, H.L., Villarreal‑Perez, J.Z., Cerda‑Flores, R.M., Figueroa, A., Sanchez‑Dominguez, C.N., Gutierrez‑Valverde, J.M. ... Martinez‑Garza, L.E. (2017). Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13, 523-529. https://doi.org/10.3892/etm.2016.3990
MLA
Gallardo‑Blanco, H. L., Villarreal‑Perez, J. Z., Cerda‑Flores, R. M., Figueroa, A., Sanchez‑Dominguez, C. N., Gutierrez‑Valverde, J. M., Torres‑Muñoz, I. C., Lavalle‑Gonzalez, F. J., Gallegos‑Cabriales, E. C., Martinez‑Garza, L. E."Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study". Experimental and Therapeutic Medicine 13.2 (2017): 523-529.
Chicago
Gallardo‑Blanco, H. L., Villarreal‑Perez, J. Z., Cerda‑Flores, R. M., Figueroa, A., Sanchez‑Dominguez, C. N., Gutierrez‑Valverde, J. M., Torres‑Muñoz, I. C., Lavalle‑Gonzalez, F. J., Gallegos‑Cabriales, E. C., Martinez‑Garza, L. E."Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study". Experimental and Therapeutic Medicine 13, no. 2 (2017): 523-529. https://doi.org/10.3892/etm.2016.3990