Open Access

Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance

  • Authors:
    • Shuaitao Shi
    • Guoquan Wang
    • Kewei Zhang
    • Zhidong Zhang
    • Kai Liang
    • Kun Li
    • Weixiao Li
    • Shuiting Zhai
  • View Affiliations

  • Published online on: March 9, 2017     https://doi.org/10.3892/etm.2017.4207
  • Pages: 1917-1921
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We investigated the expression levels and clinical significance of S100β protein in patients with vascular dementia (VD) after basal ganglia hemorrhage. From June 2014 to December 2015, in 138 patients with basal ganglia hemorrhage, we carried out the Mini‑Mental State Examination (MMSE) and Montreal Cognitive Assess­ment (MoCA) in patients on the day before the operation, the day after the operation and 9 days after the operation. Thirty-two patients (blood vessel group) had cognitive dysfunction and 106 patients (control group) had VD. One hundred thirty-eight cases of healthy adult volunteers were treated in Henan Provincial People's Hospital and were selected in the same period as healthy controls. The expression levels of serum S100β in the three groups were tested through the ELISA method and the statistical analysis was carried out. In VD patients, the serum S100β levels of patients were significantly higher than VD and healthy control groups; differences were statistically significant (P<0.05). However, there was no significant difference between those without VD after operation and the healthy control group (P>0.05). The correlation analysis was carried out with serum S100β as an independent variable and mean arterial pressure, BMI, MMSE and MoCA scores as dependent variables. Our results suggest that S100β expression levels were negatively correlated to the MMSE score (rs=-4.19) and the difference was statistically significant (P<0.05). The length of hospital stay of patients with basal ganglia hemorrhage associated with VD was significantly extended, with a mean of 23.4±2.8 days. The expression levels of S100β protein in the serum of patients with VD after basal ganglia hemorrhage was significantly increased and negatively correlated to the cognitive function of patients. Therefore, it can be used as a differential diagnosis indicator of VD after the basal ganglia hemorrhage and treatment target point of the VD.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shi S, Wang G, Zhang K, Zhang Z, Liang K, Li K, Li W and Zhai S: Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance. Exp Ther Med 13: 1917-1921, 2017
APA
Shi, S., Wang, G., Zhang, K., Zhang, Z., Liang, K., Li, K. ... Zhai, S. (2017). Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance. Experimental and Therapeutic Medicine, 13, 1917-1921. https://doi.org/10.3892/etm.2017.4207
MLA
Shi, S., Wang, G., Zhang, K., Zhang, Z., Liang, K., Li, K., Li, W., Zhai, S."Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance". Experimental and Therapeutic Medicine 13.5 (2017): 1917-1921.
Chicago
Shi, S., Wang, G., Zhang, K., Zhang, Z., Liang, K., Li, K., Li, W., Zhai, S."Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1917-1921. https://doi.org/10.3892/etm.2017.4207