Successful treatment of granulomatosis with polyangiitis with hydropneumothorax using corticosteroids and immunosuppressant

  • Authors:
    • Xu‑Hua Shi
    • Yong‑Feng Zhang
    • Yue‑Wu Lu
  • View Affiliations

  • Published online on: May 8, 2017     https://doi.org/10.3892/etm.2017.4440
  • Pages: 3586-3590
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Abstract

Pneumothorax and pleural effusion is a rare and serious complication of granulomatosis with polyangiitis (GPA). The present study reported a case with a history of sinusitis for 20 years, dry cough for three years and exacerbated purulent nasal discharge and recurrent skin ulcers for two years. The patient experienced sudden difficulty in breathing two months prior to presentation. Lung computed tomography (CT) showed multiple bilateral lung nodules and cavitary nodules as well as right hydropneumothorax. Paranasal sinus CT showed soft tissue infiltration. The cytoplasmic pattern of anti‑neutrophil cytoplasmic antibody (c‑ANCA) was positive and anti‑proteinase 3 (PR3) antibodies, erythrocyte sedimentation rate and C‑reactive protein were elevated. After pleural drainage and methylprednisolone pulse treatment, followed by cyclophosphamide and cyclosporine, the patient's symptoms were ameliorated, lungs were re‑expanded, and c‑ANCA, PR3 and inflammatory markers returned to normal levels.

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June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shi XH, Zhang YF and Lu YW: Successful treatment of granulomatosis with polyangiitis with hydropneumothorax using corticosteroids and immunosuppressant. Exp Ther Med 13: 3586-3590, 2017
APA
Shi, X., Zhang, Y., & Lu, Y. (2017). Successful treatment of granulomatosis with polyangiitis with hydropneumothorax using corticosteroids and immunosuppressant. Experimental and Therapeutic Medicine, 13, 3586-3590. https://doi.org/10.3892/etm.2017.4440
MLA
Shi, X., Zhang, Y., Lu, Y."Successful treatment of granulomatosis with polyangiitis with hydropneumothorax using corticosteroids and immunosuppressant". Experimental and Therapeutic Medicine 13.6 (2017): 3586-3590.
Chicago
Shi, X., Zhang, Y., Lu, Y."Successful treatment of granulomatosis with polyangiitis with hydropneumothorax using corticosteroids and immunosuppressant". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3586-3590. https://doi.org/10.3892/etm.2017.4440