Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways

  • Authors:
    • Wei‑Fang Li
    • Peng Wang
    • Hua Li
    • Tian‑Yi Li
    • Ming Feng
    • Su‑Fang Chen
  • View Affiliations

  • Published online on: May 31, 2017     https://doi.org/10.3892/etm.2017.4527
  • Pages: 848-854
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Oleanolic acid (OL) is a pentacyclic triterpene compound used for the treatment of hepatitis, liver fibrosis and liver cirrhosis. In China, there is no published research on the effect or biological utilization of OL on liver diseases. The aim of the present study was to investigate the protective effects of OL against diabetic cardiomyopathy and its possible mechanism. A rat model of diabetes was established using streptozotocin and the effect of OL on diabetic cardiomyopathy (DCM) was evaluated. The results demonstrated that OL significantly reversed the DCM‑induced changes to body weight, heart rate, echocardiography and hemodynamics, phosphorylated‑glycogen synthase (GS) and glycogen phosphorylase (GP) activity in diabetic rats (all P<0.01). Treatment of diabetic rats with OL significantly inhibited oxidative stress and activated heme oxygenase (HO)‑1/nuclear factor erythroid 2 (Nrf2) signaling in a rat model of diabetes (both P<0.01). The results of the present study indicate that OL protects against DCM through the HO‑1/Nrf2 and insulin modulating GS/GP signaling pathways.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li WF, Wang P, Li H, Li TY, Feng M and Chen SF: Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways. Exp Ther Med 14: 848-854, 2017
APA
Li, W., Wang, P., Li, H., Li, T., Feng, M., & Chen, S. (2017). Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways. Experimental and Therapeutic Medicine, 14, 848-854. https://doi.org/10.3892/etm.2017.4527
MLA
Li, W., Wang, P., Li, H., Li, T., Feng, M., Chen, S."Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways". Experimental and Therapeutic Medicine 14.1 (2017): 848-854.
Chicago
Li, W., Wang, P., Li, H., Li, T., Feng, M., Chen, S."Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways". Experimental and Therapeutic Medicine 14, no. 1 (2017): 848-854. https://doi.org/10.3892/etm.2017.4527