Open Access

Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery

  • Authors:
    • Xiangmei Bu
    • Bo Wang
    • Yaoqi Wang
    • Zhigang Wang
    • Chunzhi Gong
    • Feng Qi
    • Caixia Zhang
  • View Affiliations

  • Published online on: May 23, 2017     https://doi.org/10.3892/etm.2017.4504
  • Pages: 97-106
  • Copyright: © Bu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Off-pump coronary artery bypass graft (CABG) surgery has recently emerged as a means to avoid the sequelae of extracorporeal circulation, including the whole‑body inflammatory response, coagulation disorders and multiple organ dysfunction. At present, gas anesthesia, sevoflurane and intravenous anesthesia and propofol have been widely used during the CABG. To further understand the underlying mechanisms of these anesthetics on the gene level, the present study conducted pathway‑related module analysis based on a co‑expression network. This was performed in order to identify significant pathways in coronary artery disease patients who had undergone off‑pump CABG surgery before and after applying sevoflurane or propofol. A total of 269 and 129 differentially expressed genes were obtained in the sevoflurane and propofol groups, respectively. In total, eight and seven pathways (P<0.05) in the sevoflurane and propofol groups were separately obtained via Kyoto Encyclopedia of Genes and Genome pathway analysis. Finally, eight and seven pathway‑related modules in the sevoflurane and propofol groups were obtained, respectively. Furthermore, the mean degree of complement and coagulation cascades pathway‑related module in both of the groups was the highest. It was predicted that during the CABG, the anesthetics might activate the complement and coagulation systems in order to possess some cardioprotective properties.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bu X, Wang B, Wang Y, Wang Z, Gong C, Qi F and Zhang C: Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery. Exp Ther Med 14: 97-106, 2017
APA
Bu, X., Wang, B., Wang, Y., Wang, Z., Gong, C., Qi, F., & Zhang, C. (2017). Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery. Experimental and Therapeutic Medicine, 14, 97-106. https://doi.org/10.3892/etm.2017.4504
MLA
Bu, X., Wang, B., Wang, Y., Wang, Z., Gong, C., Qi, F., Zhang, C."Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery". Experimental and Therapeutic Medicine 14.1 (2017): 97-106.
Chicago
Bu, X., Wang, B., Wang, Y., Wang, Z., Gong, C., Qi, F., Zhang, C."Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery". Experimental and Therapeutic Medicine 14, no. 1 (2017): 97-106. https://doi.org/10.3892/etm.2017.4504