Open Access

Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury

  • Authors:
    • Yanpeng Hou
    • Huai'an Yang
    • Zeshi Cui
    • Xuhui Tai
    • Yanling Chu
    • Xing Guo
  • View Affiliations

  • Published online on: July 19, 2017     https://doi.org/10.3892/etm.2017.4804
  • Pages: 2461-2468
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Obstructive sleep apnea that characterized by chronic intermittent hypoxia (CIH) has been reported to associate with chronic liver injury. Tauroursodeoxycholic acid (TUDCA) exerts liver‑protective effects in various liver diseases. The purpose of this study was to test the hypothesis that TUDCA could protect liver against CIH injury. C57BL/6 mice were subjected to intermittent hypoxia for eight weeks and applied with TUDCA by intraperitoneal injection. The effect of TUDCA on liver histological changes, liver function, oxidative stress, inflammatory response, hepatocyte apoptosis and endoplasmic reticulum (ER) stress were investigated. The results showed that administration of TUDCA attenuated liver pathological changes, reduced serum alanine aminotransferase and aspartate aminotransferase level, suppressed reactive oxygen species activity, decreased tumor necrosis factor‑α and interleukin‑1β level and inhibited hepatocyte apoptosis induced by CIH. TUDCA also inhibited CIH‑induced ER stress in liver as evidenced by decreased expression of ER chaperone 78 kDa glucose-related protein, unfolded protein response transducers and ER proapoptotic proteins. Altogether, the present study described a liver‑protective effect of TUDCA in CIH mice model, and this effect seems at least partly through the inhibition of ER stress.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hou Y, Yang H, Cui Z, Tai X, Chu Y and Guo X: Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Exp Ther Med 14: 2461-2468, 2017
APA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., & Guo, X. (2017). Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Experimental and Therapeutic Medicine, 14, 2461-2468. https://doi.org/10.3892/etm.2017.4804
MLA
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14.3 (2017): 2461-2468.
Chicago
Hou, Y., Yang, H., Cui, Z., Tai, X., Chu, Y., Guo, X."Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2461-2468. https://doi.org/10.3892/etm.2017.4804