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Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates

  • Authors:
    • Jinfeng Liu
    • Gang Liu
    • Hongwei Wu
    • Zhenguang Li
  • View Affiliations

  • Published online on: July 25, 2017     https://doi.org/10.3892/etm.2017.4839
  • Pages: 2608-2612
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The clinical efficacy of pulmonary surfactant (PS) combined with assisted ventilation was assessed for acute respiratory distress syndrome (RDS) management of term neonates. The total sample size was of 60 subjects. Group I: Experimental group, 30 cases were treated with standard of care with tracheal intubation, mechanical ventilation and PS (100-200 mg/kg). In case of hypoxaemia present even after 12 h standard of care was administered again, up to 4 times. Group II: Control group, 30 cases treated with conventional tracheal intubation and mechanical ventilation. PaO2, PaO2/FiO2 and X-ray were compared between the two groups after 24-h treatment. Analysis of the results indicate that the PS combined with ventilation can improve the clinical symptoms and blood gas analysis index of ARDS neonates. The PaO2, PaCO2, PaO2/FiO2 levels were improved in the two groups after treatment, the improvement effect of the experimental group was better than in the control group, P<0.05. The surfactant therapy is proved to be effective as preventive and rescue treatment of NRDS in term neonates. This result is supported by conventional concepts and clinical confirmation in patients with lung injury-associated respiratory failure.

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September-2017
Volume 14 Issue 3

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Spandidos Publications style
Liu J, Liu G, Wu H and Li Z: Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates. Exp Ther Med 14: 2608-2612, 2017
APA
Liu, J., Liu, G., Wu, H., & Li, Z. (2017). Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates. Experimental and Therapeutic Medicine, 14, 2608-2612. https://doi.org/10.3892/etm.2017.4839
MLA
Liu, J., Liu, G., Wu, H., Li, Z."Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates". Experimental and Therapeutic Medicine 14.3 (2017): 2608-2612.
Chicago
Liu, J., Liu, G., Wu, H., Li, Z."Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2608-2612. https://doi.org/10.3892/etm.2017.4839