Assessing the impact of total extracorporeal circulation on hemodynamics in an ovine fetal model

  • Authors:
    • Fei Xiao
    • Jian Zhuang
    • Cheng‑Bin Zhou
    • Ji‑Mei Chen
    • Jian‑Zheng Cen
    • Gang Xu
    • Shu‑Sheng Wen
  • View Affiliations

  • Published online on: July 25, 2017     https://doi.org/10.3892/etm.2017.4831
  • Pages: 2709-2715
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Abstract

The present study aimed to evaluate the impact of total extracorporeal circulation on hemodynamics and placental function in an ovine fetal model. Mid‑term ovine fetuses (n=6) underwent extracorporeal circulation (30 min), cardioplegic arrest (20 min) and monitoring (120 min). The ascending aorta and umbilical cords of the fetuses were occluded during the bypass and an extracorporeal membrane oxygenator was used as the oxygen source. Biventricular intracardiac pressures, echocardiographic data, blood gas levels and placental function variables were recorded, and statistical analysis was performed using the repeated‑measure analysis of variance test. The data indicated that fetal heart rate and blood pressure at 30, 60, 90 and 120 min following the bypass were stable relative to pre‑arrest baseline (pre‑bypass) values (P>0.05). However, end diastolic pressures in the ovine right ventricles post‑bypass were significantly increased at 30, 60, 90 and 120 min relative to pre‑bypass pressures (P<0.05). The pulsatility index also increased at 30 min post‑bypass relative to the pre‑bypass score (0.91±0.06 vs. 0.61±0.14; P=0.007). The mean resistivity index at all time points post‑bypass was consistent with the pre‑bypass score (P>0.05), while the mean Tei index values for the left and right ventricles post‑bypass were significantly higher at all time points relative to pre‑bypass values (P<0.05). The pre‑bypass fetal blood pH, SaO2, base excess and lactate values were maintained during arrest (P>0.05). Fetal hemodynamics and placental function additionally remained stable for up to 2 h upon reperfusion following total extracorporeal circulation and cardioplegic arrest. Collectively these data suggest that the reproducible ovine fetal model may be useful in the evaluation of fetal cardiac surgery.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xiao F, Zhuang J, Zhou CB, Chen JM, Cen JZ, Xu G and Wen SS: Assessing the impact of total extracorporeal circulation on hemodynamics in an ovine fetal model. Exp Ther Med 14: 2709-2715, 2017
APA
Xiao, F., Zhuang, J., Zhou, C., Chen, J., Cen, J., Xu, G., & Wen, S. (2017). Assessing the impact of total extracorporeal circulation on hemodynamics in an ovine fetal model. Experimental and Therapeutic Medicine, 14, 2709-2715. https://doi.org/10.3892/etm.2017.4831
MLA
Xiao, F., Zhuang, J., Zhou, C., Chen, J., Cen, J., Xu, G., Wen, S."Assessing the impact of total extracorporeal circulation on hemodynamics in an ovine fetal model". Experimental and Therapeutic Medicine 14.3 (2017): 2709-2715.
Chicago
Xiao, F., Zhuang, J., Zhou, C., Chen, J., Cen, J., Xu, G., Wen, S."Assessing the impact of total extracorporeal circulation on hemodynamics in an ovine fetal model". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2709-2715. https://doi.org/10.3892/etm.2017.4831