Open Access

Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells

  • Authors:
    • Chenchen Feng
    • Yatfaat Ho
    • Chuanyu Sun
    • Guowei Xia
    • Qiang Ding
    • Bin Gu
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/etm.2017.4981
  • Pages: 3513-3518
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epigallocatechin gallate (EGCG) has been revealed to inhibit the proliferation and induce the apoptosis of several types of tumor, in addition to inhibiting DNA methyltransferase activity, leading to CpG demethylation. Tissue factor pathway inhibitor 2 (TFPI‑2) expression is downregulated in bladder cancer. The present study revealed that this downregulation was partly due to hypermethylation of the TFPI‑2 gene promoter, which was decreased by EGCG treatment. In addition, the present study demonstrated that EGCG could inhibit the viability and invasion, and induce the apoptosis, of bladder cancer T24 cells. Furthermore, western blot analysis and reverse transcription‑quantitative polymerase chain reaction analyses demonstrated that EGCG could upregulate the expression of TFPI‑2. These results suggest that EGCG inhibits the growth and induces the apoptosis of bladder cancer cells through restoring TFPI‑2 expression. Thus, EGCG is a potential therapeutic candidate for the treatment of bladder cancer.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Feng C, Ho Y, Sun C, Xia G, Ding Q and Gu B: Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells. Exp Ther Med 14: 3513-3518, 2017
APA
Feng, C., Ho, Y., Sun, C., Xia, G., Ding, Q., & Gu, B. (2017). Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells. Experimental and Therapeutic Medicine, 14, 3513-3518. https://doi.org/10.3892/etm.2017.4981
MLA
Feng, C., Ho, Y., Sun, C., Xia, G., Ding, Q., Gu, B."Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells". Experimental and Therapeutic Medicine 14.4 (2017): 3513-3518.
Chicago
Feng, C., Ho, Y., Sun, C., Xia, G., Ding, Q., Gu, B."Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3513-3518. https://doi.org/10.3892/etm.2017.4981